The main aim of the present study was to formulate, evaluate the extended release matrix tablets of tramadol HCl and to match the in-vitro drug release profile with the drug release criterion of the drug according to USP 37 NF 32. Extended release tablets were prepared by non-aqueous wet granulation method using HPMC K100 M, HPMC K15 M, HPMC K100 M LVP, HPMC K15 M CR, carbopol 971 NF and carbopol 71G as release retardants. The powder blend was evaluated for pre-compressional parameters like angle of repose, tapped density, bulk density, carrs index and Hausner’s ratio. Then the tablets were evaluated for post-compressional parameters viz weight variation, hardness, thickness, friability and in-vitro drug release pattern. Among all formulations F7 showed best drug release pattern which matched with drug release criterion of the drug. The drug kinetic modeling was established for zero order, first order, Higuchi and Korsemeyer peppas. The drug release mechanism confirmed that it followed first order release kinetics. From Highuchi kinetics it was concluded that most of the formulations diffusion was major release mechanism. From korsemeyer peppas, mechanism of drug release was diffusion coupled dissolution followed by erosion.
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